Anti-GBM (Goodpasture’s) Disease?

Does anti-GBM disease have another name?
Anti-GBM disease is sometimes also called Goodpasture’s disease.1 Another related term is Goodpasture syndrome, a condition that also affects the kidneys and lungs but is not caused by anti-GBM antibodies.

How common is anti-GBM disease?
Anti-GBM disease is rare, with only about 1 in 1 million new cases being reported per year.1

Who is more likely to develop anti-GBM disease?
Anti-GBM disease most often affects men in their 20s and women in their 60s, but it can occur at any age.1 The condition can occur in children, but this is extremely rare.

What causes anti-GBM disease?
Researchers don’t fully understand the cause of anti-GBM disease. A combination of your genes and factors in the environment External link may put you at risk.

Genes
Some genetic traits that parents pass on to their children, while uncommon, may affect the risk for developing anti-GBM disease. For example, scientists have found a link between anti-GBM disease and human leukocyte antigen (HLA) NIH external link, a protein on the surface of cells that plays an important role in immune response.2 Some types of HLA may increase your risk of developing the disorder, while others may decrease this risk.

Clinical Trials for Anti-GBM Disease
The NIDDK conducts and supports clinical trials in many diseases and conditions, including kidney diseases. The trials look to find new ways to prevent, detect, or treat disease and improve quality of life.

What are clinical trials for anti-GBM disease?
Clinical trials—and other types of clinical studies—are part of medical research and involve people like you. When you volunteer to take part in a clinical study, you help doctors and researchers learn more about disease and improve health care for people in the future.

What clinical studies for anti-GBM disease are looking for participants?
You can view a filtered list of clinical studies on [condition] that are federally funded, open, and recruiting at www.ClinicalTrials.gov NIH external link. You can expand or narrow the list to include clinical studies from industry, universities, and individuals; however, the National Institutes of Health does not review these studies and cannot ensure they are safe. Always talk with your health care provider before you participate in a clinical study.